COLD-ACTIVE CATALASE
Your oxidase sensor may be running out of room.
Manage peroxide. Recover oxygen. Give your biosensor more room to perform.
When oxygen becomes the bottleneck, your signal pays the price.
Oxidase-based sensors can face performance constraints as oxygen is consumed and hydrogen peroxide accumulates in the sensing layer.
Low sensitivity
A weak response to changes in analyte concentration.
Limited linear range
Early saturation across the target concentration range.
High detection limit
Insufficient response at lower analyte concentrations.
Peroxide accumulation
A reactive by-product building up in the sensing layer.
Manage peroxide.
Recover oxygen.
Cold-Active Catalase helps close the loop around the oxidase reaction—turning a reactive by-product into water and oxygen.
Dispose of peroxide while returning part of the consumed oxygen to the sensing layer.
What could Cold-Active Catalase improve in your biosensor?
A stronger signal is only the beginning. A more balanced sensing layer can give your team more useful space to develop.
Increase sensitivity
Generate a stronger response to changes in analyte concentration.
By managing peroxide and partially recovering oxygen, Cold-Active Catalase could support oxidase turnover and help increase the response produced for a given analyte concentration.
Extend the linear range
Maintain a proportional response across a broader analyte range.
Partial oxygen recovery could help the oxidase continue operating as analyte concentrations increase, potentially delaying early saturation or loss of linearity.
Lower the detection limit
Improve the ability to distinguish lower analyte concentrations.
By supporting a stronger analytical response, Cold-Active Catalase could help make low analyte concentrations easier to distinguish from the background signal.
Manage peroxide exposure
Remove a reactive by-product from the sensing layer.
Cold-Active Catalase could decompose oxidase-generated hydrogen peroxide, helping reduce peroxide exposure and maintain a more favourable environment around the immobilized enzymes.
Reported performance improvements.
Results reported with catalase in a specific conductometric glucose-biosensor architecture. Your architecture should be evaluated independently.
Cold-Active Catalase, born for demanding conditions.
Derived from an extremophile found in the Patagonian Ice Fields, with activity across demanding temperature and pH conditions and long-term storage stability.
Cold is not a constraint.
It is the starting point.
Our Cold-Active Catalase originates from an organism adapted to one of the planet’s most demanding cold environments.
Active at temperatures as low as 5°C and as high as 70°C
Temperature becomes one less thing to worry about.
Active across a broad pH range
Explore compatibility across a broad range of assay conditions.
Storage-stable for up to two years
Plan longer development programs with a stable enzyme supply.
These characteristics make Cold-Active Catalase worth evaluating as a peroxide-management component in your oxidase-based sensor.
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your biosensor.
Tell us briefly about your application. We can share full technical details and discuss how Cold-Active Catalase could be evaluated in your sensor.